Associate Scientist, Downstream Process Developmen

Are you ready to play a vital role in transforming the future of neurological disease treatment? An innovative, clinical-stage biopharma company is seeking a talented Associate Scientist, Downstream Process Development, to join their fast-growing team in Houston on a contract basis. This is a unique opportunity to advance your career in gene therapy, supporting a rapidly expanding pipeline and world-class manufacturing environment.

Position Title: Associate Scientist, Downstream Process Development

Location: Houston, TX 

Rate: $35-40/hr.

Duration: 6 months + potential extension 

About the Opportunity

This hands-on technical role supports the design, execution, and optimization of breakthrough gene therapy products. Reporting to the Associate Director, Downstream Process Development, you will contribute across a spectrum of viral vector purification activities—empowering the company’s pipeline from research through clinical and commercial production.

Be part of a collaborative and mission-driven culture that is unwavering in its commitment to patients, innovation, and scientific excellence.

Key Responsibilities

• Execute routine and complex viral vector purification, from buffer preparation and sampling to small-scale purification runs and GMP batch execution.

• Support process development operations including development and toxicology production runs, reagent prep, inventory control, and lab upkeep.

• Draft and review critical documentation, including SOPs, batch production records, process forms, and laboratory records, adhering to best practices in biotechnology and compliance.

• Collaborate cross-functionally with analytical and upstream teams to define and deliver critical quality attributes and process performance for AAV purification.

• Maintain accurate laboratory protocols and data capture, participating in inventory and equipment management, waste disposal, and lab safety procedures.

• Stay engaged with the latest advances in viral vector process development and proactively contribute to the success of the process development team.

What We’re Looking For

• BSc in Biological Science or related discipline

• 2+ years’ experience in a biotechnology or biopharma environment preferred

• Practical experience in basic laboratory operations related to virus/protein purification, buffer preparation, and aseptic technique

• Familiarity with chromatography and filtration purification methods; AKTA chromatography experience preferred

• Hands-on experience with viral vector bioprocessing, especially AAV, is an advantage

• Comfortable working in regulated environments (GLP/GMP); GMP experience is a plus

• Understanding of bioprocess documentation (SOPs, batch records) and regulatory expectations (FDA/EMA/cGMP a plus)

• Proven team player with strong organizational, communication, and problem-solving skills

• Tech-savvy with proficiency in MS Office, accurate documentation practices, and attention to detail

• Ability to work flexibly, lift up to 25 lbs frequently (50 lbs occasionally), and thrive in a laboratory setting

Why Join Us?

• Grow with a forward-thinking company at the cutting edge of gene therapy for neurological diseases

• Collaborate with industry experts and contribute to life-changing therapies

• Advance your skills in a highly supportive, innovation-focused culture

• Be part of a Houston-based organization with an end-to-end manufacturing footprint, setting the stage for personal and professional growth

Take your next step in the gene therapy revolution. Apply your expertise in downstream process development to truly make a difference for patients and families facing rare diseases.

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